Job: (Senior) Scientist, Antigen and Product Discovery, Repertoire Immune Medicines, Cambridge, MA

General Information

Job title:
(Senior) Scientist, Antigen and Product Discovery
Job location:
Cambridge, MA 02912 United States

Requisition code:
Date posted:
Job type:

Career path:

Scientific Discipline:

Job Description

• Lead effort to prioritize and validate tumor T cell targets for Repertoire's Immuno-oncology program in collaboration with multiple other teams. Contribute tounderstanding of biological properties of candidate targets.
• Drive innovative research into effector-target interactions in ex-vivo cell culture models oftumor immunotherapy. Establish and culture 2D and 3D tumor cell lines and T cell co-culture systems.
• Collaborate with the Cell Therapy Discovery team to ensure the development of robustmethods for ex-vivo T cell priming to novel classes of tumor antigens.
• Contribute to the development of functional immunological and analytical methods tocharacterize the response of the T cell product to cancer specific antigens, such as multi-color flow cytometry and sorting, T cell co-culture systems, MHC/peptide tetrameranalysis, ELISpot, Luminex, and other related immune assays.
• Independently plan and execute experimental projects with minimal supervision.
• Capture primary data and document work as required in Electronic Laboratory Notebook(ELN), maintaining up to date records.
• Train research associates to accomplish program and company goals within designatedtimelines.
• Analyze, summarize and communicate data to team leadership and project teams.

Job Requirements

• Ph.D., M.D. in Immunology or Cancer Biology with minimum of 2 years of workingexperience in academia or industry, M.S. with more than 5 years, or B.S. with more than7 years of working experience in immunology / oncology.
• Expert in the development and application of T cell immunology or tumor biology relatedassays.
• In-depth experience with general in vitro cell culture / immunology techniques, includingculture of primary cell lines.
• Strong mastery of multi-color flow cytometry for T cell characterization.
• Experience with T cell-based assays such as MHC/peptide tetramer, ELISpot, Luminex,cytotoxicity, and TCR sequencing is a plus.
• Experience with 3D tumor spheroid assays is a plus.
• Experience with TIL isolation, culture and phenotyping is a plus.
• Highly adaptable and responsive to evolving strategic, technical and businessopportunities.

(Job number: 3924890)